AI-Powered Protein Design for Cell Therapy

Biology is a barrier to cancer treatment

Today, only a tiny fraction of cancers can be cured. This is because cancer is a complex biological system, and our bodies have learned to make the wrong decisions as they fight. Our immune system evolved to beat back infections, not our own cells. Even the most advanced cancer treatments fail to address this.

Rather than one gene or one protein solutions that reuse existing biomolecules, we need to create better biology that can address the multiple mechanisms that stand in the way of curing tumors.

What is protein design?

Proteins are the biological unit of function. Creating new ones will transform medicine.

Natural proteins represent only a sliver of the potential biological universe. By designing new protein functions, Outpace Bio™*can guide cells to recognize and eliminate cancer in the body. Our co-founders pioneered a new era in protein design, shifting from designing structures to new biological functions.

Why build cell therapies?

We know that cell therapies have the potential to cure cancer, but less than ~5% of cancer burden can be addressed with existing technology.

To cure cancer, multiple problems must be solved simultaneously: 1) the tumor suppresses our immune response, 2) the cell therapy does not persist, 3) the cell therapy has limited potency, safety, and specificity, and 4) ex vivo manufacturing and delivery limit who can be treated.
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By programming cells to make the right decisions inside patients, Outpace Bio™ technologies stimulate productive immune responses in the tumor microenvironment (OUTSMART™), enable potent and persistent cell therapy activity (OUTLAST™), maximize the potency and specificity of engineered receptors (OUTSPACER™, OUTMATCH™) with built-in safety (OUTSAFE™), and deliver them in vivo for scalable access (OUTDRIVE™), across diverse cancer indications.

We program cells to make the right decisions

Our Science

Outpace Bio uses AI-powered protein design to create proteins that program engineered cells for improved function inside patients.

We combine them to develop cell therapy products with curative potential.

Our platform technologies can power any cell type and manufacturing approach.

OUTSPACER™ optimized CAR

Maximize Potency, Specificity, & Safety

The Problem: Optimal immunologic synapse geometry is crucial for cell therapy potency.

Our Solution: OUTSPACER™ library consists of fully human sequences that maximize CAR T cell function, leading to more potent killing of cancer cells.

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OUTSMART™ designed cytokine

Enhanced Communication to Stimulate Immune Response
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The Problem: Solid tumors produce the wrong cytokines, blunting the activity of immune cells.

Our Solution: Cell therapy with OUTSMART™ cytokines can stimulate immune cells in the tumor, boosting efficacy and safety by enabling a productive immune response.

OUTLAST™ T cell persistence

Better Decisions Inside Patients Enhance Cell Therapy Persistence
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The Problem: Immune cells naturally turn off when fighting cancer.

Our Solution: OUTLAST™ technology reprograms cell therapies to make better decisions inside patients with the goal of achieving a durable clinical response.

OUTMATCH™ optimized TCR

‍Strong Surface Expression of Properly Paired TCR α/β Chains‍

‍The Problem: Engineered TCRs mispair with native TCRs; other approaches require complicated gene editing.

‍Our Solution: Protein design enables strong surface expression of properly paired α/β chains without the need for gene knockout or knock-in.

OUTDRIVE™ in vivo delivery

Overcome the Key Challenges for In Vivo T Cell Therapies‍

‍The Problem: Existing solutions trade off between cost and safety, and existing transgenes cannot drive efficacy in lymphoreplete patients.

‍Our Solution: Scalable in vivo delivery with durable efficacy via OUTTech transgenes, and durable safety via increased specificity, reduced systemic activation, and no lymphodepletion.

OUTSAFE™ safety switch

Maximize Potency, Specificity, & Safety

The Problem: Powerful cell therapies require advanced safety features.

Our Solution: EGFRopt^TM is a fully human safety switch that responds to cetuximab and can also be used for cell selection and QC during ex vivo manufacturing.

Our Approach

We pioneered the design of new biological function. Now we’re building the future in which all cell therapies are effective, safe, and scalable.

Biology is a barrier to cancer treatment

What is protein design?

Proteins are the biological unit of function. Creating new ones will transform medicine.

Natural proteins represent only a sliver of the potential biological universe. By designing new protein functions, we can guide cells to recognize and eliminate cancer in the body. Our co-founders pioneered a new era in protein design, shifting from designing structures to new biological functions.

Why build cell therapies?

We know that cell therapies have the potential to cure cancer. By programming cells to make the right decisions inside patients, Outpace Bio™ technologies stimulate productive immune responses in the tumor microenvironment (OUTSMART™), enable potent and persistent cell therapy activity (OUTLAST™), maximize the potency and specificity of engineered receptors (OUTSPACER™, OUTMATCH™) with built-in safety (OUTSAFE™), and deliver them in vivo for scalable access (OUTDRIVE™).

We’re building a future in which all cell therapies are effective, safe, and scalable.

SWIPE

We program cells to make the right decisions

Our Science

We create technologies to dramatically improve the efficacy & safety of cell therapies and combine them to develop best-in-class cell therapy products. Our platform technologies can power any cell type and manufacturing approach.

OUTSPACER^TM optimized CAR

Maximize Potency, Specificity, & Safety

The Problem: Optimal immunologic synapse geometry is crucial for cell therapy potency.

Our Solution: The OUTSPACER^TM library consists of fully human sequences that maximize CAR T cell function, leading to more potent killing of cancer cells.

OUTSMART™ designed cytokine

Enhanced Communication to Stimulate Immune Response

The Problem: Solid tumors produce the wrong cytokines, blunting the activity of immune cells.

Our Solution: Cell therapies with OUTSMART™ cytokines can stimulate immune cells in the tumor, boosting efficacy and safety by enabling a productive immune response.

OUTLAST™ T cell persistence

Better Decisions Inside Patients Enhance Cell Therapy Persistence

The Problem: Immune cells naturally turn off when fighting cancer.

Our Solution: OUTLAST™ technology reprograms cell therapies to make better decisions inside patients with the goal of achieving a durable clinical response.

OUTMATCH™ optimized TCR

‍Strong Surface Expression of Properly Paired TCR α/β Chains

‍‍The Problem: Engineered TCRs mispair with native TCRs; other approaches require complicated gene editing.

‍Our Solution: Protein design enables strong surface expression of properly paired α/β chains without the need for gene knockout or knock-in.

OUTDRIVE™ in vivo delivery

Overcome the Key Challenges for In Vivo T Cell Therapies

‍‍The Problem: Existing solutions trade off between cost and safety, and existing transgenes cannot drive efficacy in lymphoreplete patients.

‍Our Solution: Scalable in vivo delivery with durable efficacy via OUTTech transgenes, and durable safety via increased specificity, reduced systemic activation, and no lymphodepletion.

OUTSAFE™ safety switch

Maximize Potency, Specificity & Safety
‍
The Problem: Powerful cell therapies require advanced safety features.

Our Solution: EGFRopt™ is a fully human safety switch that responds to cetuximab and can also be used for cell selection and QC during ex vivo manufacturing.

Biology and technology. Seamlessly integrated.

Computational & Structural Biology

Synthetic Biology & Rapid Prototyping

Cell Programming

Translational Immunology

Protein design
Biostatistics
Next gen sequencing analysis

>100,000 hours of protein design experience

Cloning
Protein production
Lenti production
Automation

>15,000 constructs tested

Regulated promoters
Controlled cytokines
Autonomous protein regulators

Expansive parts library & stackable assets that solve barriers to efficacy & safety

Robust in-house translational models
Deep disease area expertise

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IND engine for engineered
cell therapies

Computational &
Structural Biology

Protein design
Biostatistics
Next gen sequencing analysis

>100,000 hours of protein design experience

Synthetic Biology
Foundry

Cloning
Protein production
Lenti production
Automation

>15,000 constructs tested

Cell Programming

Regulated Promoters
Controlled Cytokines
Autonomous Protein Regulators

Expansive parts library & stackable assets that solve barriers to efficacy & safety

Translational
& Immunology

IND engine for engineered
cell therapies

Robust in-house translational models and expertise

We're revolutionizing cell therapy with protein design.

With better biology, we will cure cancer.

Our Approach

Biology is a barrier to cancer treatment

What is protein design?

Why build cell therapies?

We program cells to make the right decisions

Our Approach

We program cells to make the right decisions

Biology and technology. Seamlessly integrated.

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